Synthesis of thiostatins (major acute-phase α1 proteins) in different strains of Rattus norvegicus

Tim Cole, Gerhard Schreiber

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2 Citations (Scopus)


1. 1. Two different thiostatin proteins were detected by crossed immunoelectrophoresis in plasma of the following inbred strains of Rattus norvegicus; Wistar, Sprague, Dawley, Hooded Wistar, Lewis, Porton-Albino, ACI, Long Evans, and Katholiek, a mutant strain of the Brown Norway. 2. 2. Only one thiostatin protein was detected using crossed immunoelectrophoresis in plasma from the Buffalo rat. 3. 3. Comparison of partially purified thiostatins from Buffalo, Wistar, and Sprague Dawley rats in polyacrylamide gels showed that the thiostatin protein in Buffalo rat plasma corresponded to thiostatin 1 of the two thiostatins of the Wistar and Sprague Dawley rats. 4. 4. Thiostatin 1 mRNA and thisotatin 2 mRNA, of approximately 1.7 kilobases, were both demonstrated in RNA from Buffalo rat liver.

Original languageEnglish
Pages (from-to)813-818
Number of pages6
JournalComparative Biochemistry and Physiology Part B: Comparative Biochemistry
Issue number4
Publication statusPublished - 1989
Externally publishedYes

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