Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

Geoffrey M. Williams, Garth J S Cooper, Kathryn Lee, Lynda Whiting, Margaret A. Brimble

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to manage the condition, diabetic individuals remain prone to complications that are detrimental to both their length and quality of life. An improved understanding of the disease which may then enable development of new treatments is therefore a desirable goal. Vesiculin, a novel IGF-II-like protein was recently isolated from the secretory granules of murine β-cells, and preliminary studies indicate it is capable of signalling via the insulin receptor (IR)/insulin-like growth factor receptor 1(IGF1R) family giving it the potential to elicit both metabolic and mitogenic responses in the beta-cell. In order to facilitate further studies on this new member of the insulin-family of hormones, we undertook a chemical synthesis of the protein using regioselective disulfide bond formation.

Original languageEnglish
Pages (from-to)3145-3150
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number19
DOIs
Publication statusPublished - 2013
Externally publishedYes

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