Synthesis of 14C-labelled sulforaphane

Nikolai Kuhnert; Birgit Holst; Gary Williamson

doi:10.1002/jlcr.462

Synthesis of ¹⁴C-labelled sulforaphane

Nikolai Kuhnert, Birgit Holst, Gary Williamson

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of ¹⁴C-labelled SFN.

Original language	English
Pages (from-to)	347-354
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/jlcr.462
Publication status	Published - 12 May 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C-labelling
Anti-cancer compounds
Isothiocyanates
Phytochemicals

Access to Document

10.1002/jlcr.462

Cite this

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AU - Holst, Birgit

AU - Williamson, Gary

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N2 - Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of 14C-labelled SFN.

AB - Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of 14C-labelled SFN.

KW - C-labelling

KW - Anti-cancer compounds

KW - Isothiocyanates

KW - Phytochemicals

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M3 - Article

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