Synthesis of 14C-labelled sulforaphane

Nikolai Kuhnert; Birgit Holst; Gary Williamson

doi:10.1002/jlcr.462

Synthesis of ¹⁴C-labelled sulforaphane

Nikolai Kuhnert, Birgit Holst, Gary Williamson

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of ¹⁴C-labelled SFN.

Original language	English
Pages (from-to)	347-354
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/jlcr.462
Publication status	Published - 12 May 2001
Externally published	Yes

Keywords

C-labelling
Anti-cancer compounds
Isothiocyanates
Phytochemicals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jlcr.462

Cite this

@article{80079bbfd5b2413190edcea70e8cc5c9,

title = "Synthesis of 14C-labelled sulforaphane",

abstract = "Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of 14C-labelled SFN.",

keywords = "C-labelling, Anti-cancer compounds, Isothiocyanates, Phytochemicals",

author = "Nikolai Kuhnert and Birgit Holst and Gary Williamson",

year = "2001",

month = may,

day = "12",

doi = "10.1002/jlcr.462",

language = "English",

volume = "44",

pages = "347--354",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Synthesis of 14C-labelled sulforaphane

AU - Kuhnert, Nikolai

AU - Holst, Birgit

AU - Williamson, Gary

PY - 2001/5/12

Y1 - 2001/5/12

N2 - Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of 14C-labelled SFN.

AB - Sulforaphane (SFN) a naturally occurring isothiocyanate present in broccoli, shows strong evidence of anti-carcinogenic activity. The mechanism of action, absorption, distribution, metabolism and excretion of the compound is however still poorly understood and requires a radiolabelled version of the compound for further studies. The paper describes an optimised cold synthesis of SFN and a radiosynthesis of 14C-labelled SFN.

KW - C-labelling

KW - Anti-cancer compounds

KW - Isothiocyanates

KW - Phytochemicals

UR - http://www.scopus.com/inward/record.url?scp=0035037956&partnerID=8YFLogxK

U2 - 10.1002/jlcr.462

DO - 10.1002/jlcr.462

M3 - Article

AN - SCOPUS:0035037956

SN - 0362-4803

VL - 44

SP - 347

EP - 354

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 5

ER -