Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Bich Anh Chau, Grant Raymond Drummond, William Roy Jackson, Bevyn Jarrott, Alyson Anne Miller, Kamani Rupika Subasinghe, Christina Yan Ru Tan, Paul James White, Christine E Wright, James Ziogas

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Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active.
Original languageEnglish
Pages (from-to)634-639
Number of pages6
Issue number4
Publication statusPublished - 2015

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