TY - JOUR
T1 - Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents
AU - Chau, Bich Anh
AU - Drummond, Grant Raymond
AU - Jackson, William Roy
AU - Jarrott, Bevyn
AU - Miller, Alyson Anne
AU - Subasinghe, Kamani Rupika
AU - Tan, Christina Yan Ru
AU - White, Paul James
AU - Wright, Christine E
AU - Ziogas, James
PY - 2015
Y1 - 2015
N2 - Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active.
AB - Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active.
UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/md/c4md00459k
U2 - 10.1039/c4md00459k
DO - 10.1039/c4md00459k
M3 - Article
SN - 2040-2503
VL - 6
SP - 634
EP - 639
JO - MedChemComm
JF - MedChemComm
IS - 4
ER -