Synthesis of new metal complex - Bioinolecule hybrids as redox sensors for specific nucleobases

G. Gasser, A. M. Bond, B. Graham, Z. Kosowski, L. Spiccia

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Abstract

This article describes the synthesis, characterization and Zn(II) complexation properties of a macrocyclic tetraamine ligand derivative of 1,4,7,10-tetraazacyclododecane (cyclen) (1) bearing a ferrocenyl pendant arm. Functionalization of cyclen with the ferrocenyl group has been accomplished according to a published method. NMR spectroscopy has been used to establish that the ligand forms a Zn2+ complex with a 1:1 stoichiometry. We have investigated the change in the redox properties of the metal-free ligand 1, the Zn2+ complex and the Zn2+ complex following addition of the DNA base thymine (T) in acetonitrile as solvent. The electrochemical data indicate a significant change in the redox potential of the ferrocenyl group on addition of zinc ions to the macrocycle-ferrocenyl adduct. Addition of thymine to the complex caused only a minor change in electrochemical response, which indicated that this Zn(II)-ferrocene hybrid is unlikely to useful as a thymine sensor under the conditions used in our experiments.

Original languageEnglish
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages412-415
Number of pages4
Publication statusPublished - 2005
EventNanotechnology Conference and Trade Show (Nanotech) 2005 - Anaheim, California, USA, Anaheim, United States of America
Duration: 8 May 200512 May 2005

Conference

ConferenceNanotechnology Conference and Trade Show (Nanotech) 2005
Abbreviated titleNSTI Nanotech 2005
CountryUnited States of America
CityAnaheim
Period8/05/0512/05/05

Keywords

  • Biosensor
  • Electrochemistry
  • Ferrocene-macrocycle derivative
  • Nucleobase
  • Zinc complex

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