Synthesis of mesoporous silica/reduced graphene oxide sandwich-like sheets with enlarged and "funneling" mesochannels

Yupu Liu, Wei Li, Dengke Shen, Chun Wang, Xiaomin Li, Manas Pal, Renyuan Zhang, Lei Chen, Chi Yao, Yong Wei, Yuhui Li, Yujuan Zhao, Hongwei Zhu, Wenxing Wang, Ahmed Mohamed El-Toni, Fan Zhang, Dongyuan Zhao

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31 Citations (Scopus)

Abstract

Here, we report the synthesis of reduced graphene oxide@mesoporous silica (denoted as rGO@mSiO2) sandwich-like sheets by an oil–water biphase stratification approach. The resultant rGO@mSiO2 nanosheets possess a uniform sandwich-like structure, ultrathin thickness (∼50 nm), large aspect ratio, high surface area (∼755 m2/g), and enlarged and tunable pore size (from 2.8 to 8.9 nm). Significantly, the mesochannels are oriented perpendicularly to graphene surfaces and shaped like a funnel, which facilitates drug loading and releasing. The influences of the concentration of precursor, solvent, GO sheet, and reaction temperature on the formation of the sandwich-like rGO@mSiO2 nanosheets have been systematically investigated. The resultant nanosheets with a pore size of ∼8.9 nm show the maximum loading capacity of bovine β-lactoglobulin (55.1 wt %). The protein releasing process in the simulated body fluid suggests that the release can be controlled from 20 to 60 h simply by adjusting the pore size. In addition, the degradability of rGO@mSiO2 nanosheets can be well-controlled by tuning the pore size as well. Most importantly, the nanosheets exhibit a rapid photothermal heating under the near infrared (NIR) irradiation. Therefore, the resultant nanosheets would have a hopeful prospect in a large–molecule–weight drug delivery system, which have both the chemical and photothermal therapeutic functions.
Original languageEnglish
Pages (from-to)5577-5586
Number of pages10
JournalChemistry of Materials
Volume27
Issue number16
DOIs
Publication statusPublished - 25 Aug 2015
Externally publishedYes

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