Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity

Rick Morrison, Zhaohua Zheng, Ian G. Jennings, Philip E. Thompson, Jasim M A Al-Rawi

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5 Citations (Scopus)

Abstract

To continue our study of 2-morpholino-benzoxazine based compounds, which show useful activity against PI3K family enzymes or antiplatelet activity, we designed and synthesized a series of linear 6.7-fused, 5,6-angular fused and 7,8-angular fused-aryl-morpholino-naphth-oxazines. The compounds were prepared from substituted 2-hydroxynaphthoic acid to give the corresponding thioxo analogues 8, 9, 15 and 19. The thioxo products were then converted to the morpholino substituted analogue. The aryl group was introduced by Suzuki coupling of bromo precursors. The products were evaluated for activity at PI3K family enzymes and as platelet aggregation inhibitors and compared to reported unsubstituted analogues. The linear 6.7-fused product 13a and 13b were moderated potent but selective PI3Kδ isoform inhibitors (IC50 = 7.7 and 5.61 μM). Good antiplatelet activity was noticed for the angular 7,8-fused compounds 22a, b, k and l with IC50 = 3.0,14.0, 2.0 and 5.0 μM respectively. The antiplatelet activity is independent of PDE3.

Original languageEnglish
Pages (from-to)5534-5538
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number22
DOIs
Publication statusPublished - 2016

Keywords

  • 5,6-Angular fused and 7,8-angular fused-aryl-morpholino-naphth-oxazines
  • 6.7-Fused
  • DNA-PK
  • PDE3A antiplatelet activity
  • PI3K

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