@article{cb34ded676a540699f3b2d4990e18b3f,
title = "Synthesis of indolostilbenes via FeCl3-promoted oxidative cyclisation and their biological effects on NG108-15 cell viability and H2O2-induced cytotoxicity",
abstract = "A convenient and simple radical cation cyclisation of 3,5-dimethoxystilbene was developed using the commercially available FeCl3under mild condition. It enabled the construction of a new class of indolostilbenes (i.e., indole-stilbene hybrid). Various parameters were investigated to obtain better yields (more than 42%) compared with the previously reported. The synthesised indolostilbenes were characterised, and their mechanism of formation was discussed. The synthesised compounds were submitted for biological assay on NG108-15 cell viability and H2O2-induced cytotoxicity. The result showed that two indolostilbenes have promising protective activity against H2O2.",
keywords = "cyclisation, FeCloxidative coupling, HOprotective properties, Indolostilbene, pericyclic reaction",
author = "Azmi, {Mohamad Nurul} and Sian, {Tan Aik} and Munirah Suhaimi and Kamarudin, {Muhamad Noor Alfarizal} and Din, {Mohd Fadzli Md} and Nafiah, {Mohd Azlan} and Thomas, {Noel F.} and Kadir, {Habsah Abdul} and Khalijah Awang",
note = "Funding Information: This research is dedicated to the memory of Kartini A. The authors are grateful to the Universiti Sains Malaysia Fellowship Scheme (TAS). This research was supported by the MyPair PHC Hibiscus (203.PKIMIA. 6782002). Publisher Copyright: {\textcopyright} Penerbit Universiti Sains Malaysia, 2021. This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).",
year = "2021",
doi = "10.21315/JPS2021.32.1.6",
language = "English",
volume = "32",
pages = "69--89",
journal = "Journal of Physical Science",
issn = "1675-3402",
publisher = "Penerbit Universiti Sains Malaysia",
number = "1",
}