TY - JOUR
T1 - Synthesis of heterotelechelic poly(ethylene glycol)s and their characterization by MALDI-TOF-MS
AU - Völcker, Nicolas Hans
AU - Klee, Doris
AU - Hanna, Martin
AU - Höcker, Hartwig
AU - Bou, Jordi J.
AU - De Ilarduya, Antxon Martínez
AU - Muñoz-Guerra, Sebastiän
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Two heterotelechelic poly(ethylene glycol)s were synthezised by end group modification of α-hydro-ω-hydroxy-poly(oxyethylene) (PEG). The first reaction route starts from heterobifunctional α-hydro-ω-octadecanoyloxy-poly(oxyethylene) (400) and comprises the synthesis of α-hydro-ω-carboxymethoxy-poly(oxyethylene). The second pathway starts from homotelechelic PEG(400) and leads to α-(2-propenyl)-ω-carboxymethylthio-poly(oxyethylene). Purification of the desired products was accomplished by means of ion exchange chromatography on DEAE Sephadex. PEG derivatives were characterized by means of NMR, IR, HPLC and GPC. MALDI-TOF-MS recorded in the reflectron mode served as a fine method that provides information on chemical composition as well as molecular weight.
AB - Two heterotelechelic poly(ethylene glycol)s were synthezised by end group modification of α-hydro-ω-hydroxy-poly(oxyethylene) (PEG). The first reaction route starts from heterobifunctional α-hydro-ω-octadecanoyloxy-poly(oxyethylene) (400) and comprises the synthesis of α-hydro-ω-carboxymethoxy-poly(oxyethylene). The second pathway starts from homotelechelic PEG(400) and leads to α-(2-propenyl)-ω-carboxymethylthio-poly(oxyethylene). Purification of the desired products was accomplished by means of ion exchange chromatography on DEAE Sephadex. PEG derivatives were characterized by means of NMR, IR, HPLC and GPC. MALDI-TOF-MS recorded in the reflectron mode served as a fine method that provides information on chemical composition as well as molecular weight.
UR - http://www.scopus.com/inward/record.url?scp=0001741890&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1521-3935(19990601)200:6<1363::AID-MACP1363>3.0.CO;2-A
DO - 10.1002/(SICI)1521-3935(19990601)200:6<1363::AID-MACP1363>3.0.CO;2-A
M3 - Article
AN - SCOPUS:0001741890
SN - 1022-1352
VL - 200
SP - 1363
EP - 1373
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
IS - 6
ER -