Abstract
Microwave irradiation has found its niche in organic synthesis and has been actively used for the green synthesis of heterocycles. This chapter demonstrates the utility of microwave irradiation in promoting classical name reactions and the benefits of such an approach compared to the reactions under conventional heating. The selected examples cover the synthesis of pyrroles, furans, thiophenes, pyrazoles, imidazole, oxazoles, thiazoles, triazoles, tetrazoles, indoles, pyridines, and quinolines using 29 name reactions. Some examples of applications of these methods for preparing bioactive molecules, including medicines and natural products, are also discussed. To ensure the safety and reproducibility of selected methods, we focus on reactions performed in dedicated microwave reactors under monitoring and controlling reaction parameters.
| Original language | English |
|---|---|
| Title of host publication | Green Chemical Synthesis with Microwaves and Ultrasound |
| Editors | Dakeshwar Kumar Verma, Chandrabhan Verma, Paz Otero Fuertes |
| Place of Publication | Weinheim Germany |
| Publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
| Chapter | 6 |
| Pages | 157-184 |
| Number of pages | 28 |
| ISBN (Electronic) | 9783527844494, 9783527844470, 9783527844487 |
| ISBN (Print) | 9783527352975 |
| DOIs | |
| Publication status | Published - 2024 |
Keywords
- heterocycle
- imidazole
- indole
- microwave irradiation
- oxazole
- pyridine
- pyrrole
- quinoline
- thiophene
- triazole