Synthesis of Heterocyclic Compounds Under Microwave Irradiation Using Name Reactions

Sheryn Wong, Anton V. Dolzhenko

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

Microwave irradiation has found its niche in organic synthesis and has been actively used for the green synthesis of heterocycles. This chapter demonstrates the utility of microwave irradiation in promoting classical name reactions and the benefits of such an approach compared to the reactions under conventional heating. The selected examples cover the synthesis of pyrroles, furans, thiophenes, pyrazoles, imidazole, oxazoles, thiazoles, triazoles, tetrazoles, indoles, pyridines, and quinolines using 29 name reactions. Some examples of applications of these methods for preparing bioactive molecules, including medicines and natural products, are also discussed. To ensure the safety and reproducibility of selected methods, we focus on reactions performed in dedicated microwave reactors under monitoring and controlling reaction parameters.

Original languageEnglish
Title of host publicationGreen Chemical Synthesis with Microwaves and Ultrasound
EditorsDakeshwar Kumar Verma, Chandrabhan Verma, Paz Otero Fuertes
Place of PublicationWeinheim Germany
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Chapter6
Pages157-184
Number of pages28
ISBN (Electronic)9783527844494, 9783527844470, 9783527844487
ISBN (Print)9783527352975
DOIs
Publication statusPublished - 2024

Keywords

  • heterocycle
  • imidazole
  • indole
  • microwave irradiation
  • oxazole
  • pyridine
  • pyrrole
  • quinoline
  • thiophene
  • triazole

Cite this