Synthesis of functional miktoarm star polymers in an automated parallel synthesizer

Chao Chen, Friederike Richter, Junliang Zhang, Carlos Guerrero-Sanchez, Anja Traeger, Ulrich S. Schubert, Anchao Feng, San H. Thang

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Abstract

A feasibility study for the synthesis of well-defined miktoarm star polymers containing peptide arms in an automated parallel synthesizer is reported. A series of linear homo- and block (co–)polymers were prepared in the presence of commercial or peptide-functionalized reversible addition-fragmentation chain transfer (RAFT) agents. Thereafter, miktoarm star polymers were obtained by cross-linking different combinations of the abovementioned linear polymers using N, N'-bis(acryloyl)cystamine (BAC) as a redox responsive cross-linker. The described automated synthesis can be regarded as a proof-of-principle technique that next to emerging automated polymer purification and machine learning approaches could be useful to potentiate the development of autonomous methods for accessing systematic and comprehensive (peptide-)functionalized star polymer libraries. With these approaches hundreds of candidates of these complex polymer architectures could be rapidly synthesized, screened and optimized for different applications.

Original languageEnglish
Article number110777
Number of pages7
JournalEuropean Polymer Journal
Volume160
DOIs
Publication statusPublished - 5 Nov 2021

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