Abstract
As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.
Original language | English |
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Article number | M454 |
Pages (from-to) | M454/1 - M454/2 |
Number of pages | 1 |
Journal | Molbank |
Volume | 2005 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2005 |
Keywords
- Amidine
- Clozapine
- Dibenzodiazepine
- P-tolyloxypropyl analogue