Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine

Ben Capuano; Ian T. Crosby; Sean E.K. Lim; Edward J. Lloyd

doi:10.3390/M454

Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine

Ben Capuano, Ian T. Crosby, Sean E.K. Lim, Edward J. Lloyd

Medicinal Chemistry

Research output: Contribution to journal › Article › Other

1 Citation (Scopus)

Abstract

As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.

Original language	English
Article number	M454
Pages (from-to)	M454/1 - M454/2
Number of pages	1
Journal	Molbank
Volume	2005
Issue number	6
DOIs	https://doi.org/10.3390/M454
Publication status	Published - Dec 2005

Keywords

Amidine
Clozapine
Dibenzodiazepine
P-tolyloxypropyl analogue

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title = "Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine",

abstract = "As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.",

keywords = "Amidine, Clozapine, Dibenzodiazepine, P-tolyloxypropyl analogue",

author = "Ben Capuano and Crosby, {Ian T.} and Lim, {Sean E.K.} and Lloyd, {Edward J.}",

note = "Funding Information: The authors gratefully acknowledge financial support from Monash University and the assistance of Ms Anna Podloucka and Mr James Shin. Publisher Copyright: {\textcopyright} 2005 MDPI. All rights reserved.",

year = "2005",

month = dec,

doi = "10.3390/M454",

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AU - Capuano, Ben

AU - Crosby, Ian T.

AU - Lim, Sean E.K.

AU - Lloyd, Edward J.

N1 - Funding Information: The authors gratefully acknowledge financial support from Monash University and the assistance of Ms Anna Podloucka and Mr James Shin. Publisher Copyright: © 2005 MDPI. All rights reserved.

PY - 2005/12

Y1 - 2005/12

N2 - As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.

AB - As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.

KW - Amidine

KW - Clozapine

KW - Dibenzodiazepine

KW - P-tolyloxypropyl analogue

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U2 - 10.3390/M454

DO - 10.3390/M454

M3 - Article

SN - 1422-8599

VL - 2005

SP - M454/1 - M454/2

JO - Molbank

JF - Molbank

IS - 6

M1 - M454

ER -

Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine

Abstract

Keywords

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