Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e] [1,4]diazepine

Ben Capuano, Ian T. Crosby, Sean E.K. Lim, Edward J. Lloyd

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Abstract

As part of our ongoing research programme in the area of anti-schizophrenia therapeutics, we have synthesized the title compound based on the structural hybridization of the two prominent antipsychotic drugs, clozapine and haloperidol. The starting tricyclic lactam, 1, was synthesized according to previously described literature procedures [1, 2, 3]. Subsequent treatment of 1 with the titanium-amine complex [4] formed from the addition of titanium tetrachloride to the monosubstituted piperazine, 2, furnished the title compound 3 in respectable yield.

Original languageEnglish
Article numberM454
Pages (from-to)M454/1 - M454/2
Number of pages1
JournalMolbank
Volume2005
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Amidine
  • Clozapine
  • Dibenzodiazepine
  • P-tolyloxypropyl analogue

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