Synthesis of 2-substituted pyrazolo[3,4-d]pyrimidines

Graham Smith; Graham Smith; Graham Smith; Peter J. Scammells

doi:10.1071/CH9911795

Synthesis of 2-substituted pyrazolo[3,4-d]pyrimidines

Graham Smith, Graham Smith, Graham Smith, Peter J. Scammells

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The reaction of 1-acetyl-2-phenylhydrazine with ethoxymethylenemalononitrile yielded [(4-cyano-1-phenylpyrazol-3-yl)aminomethylene]propanedinitrile. Hydrolysis followed by annulation with methyl isocyanate provided a synthetic route to 2-phenylpyrazolo[3,4-d]pyrimidines. © 1991 ASEG.

Original language	English
Pages (from-to)	1795-1801
Number of pages	7
Journal	Australian Journal of Chemistry
Volume	44
Issue number	12
DOIs	https://doi.org/10.1071/CH9911795
Publication status	Published - 1 Jan 1991

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title = "Synthesis of 2-substituted pyrazolo[3,4-d]pyrimidines",

abstract = "The reaction of 1-acetyl-2-phenylhydrazine with ethoxymethylenemalononitrile yielded [(4-cyano-1-phenylpyrazol-3-yl)aminomethylene]propanedinitrile. Hydrolysis followed by annulation with methyl isocyanate provided a synthetic route to 2-phenylpyrazolo[3,4-d]pyrimidines. {\textcopyright} 1991 ASEG.",

author = "Graham Smith and Graham Smith and Graham Smith and Scammells, {Peter J.}",

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AU - Scammells, Peter J.

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N2 - The reaction of 1-acetyl-2-phenylhydrazine with ethoxymethylenemalononitrile yielded [(4-cyano-1-phenylpyrazol-3-yl)aminomethylene]propanedinitrile. Hydrolysis followed by annulation with methyl isocyanate provided a synthetic route to 2-phenylpyrazolo[3,4-d]pyrimidines. © 1991 ASEG.

AB - The reaction of 1-acetyl-2-phenylhydrazine with ethoxymethylenemalononitrile yielded [(4-cyano-1-phenylpyrazol-3-yl)aminomethylene]propanedinitrile. Hydrolysis followed by annulation with methyl isocyanate provided a synthetic route to 2-phenylpyrazolo[3,4-d]pyrimidines. © 1991 ASEG.

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SP - 1795

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JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 12

ER -

Synthesis of 2-substituted pyrazolo[3,4-d]pyrimidines

Abstract

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