1,1,3,3-Tetraalkylisoindolines are important intermediates in the preparation of stable nitroxides, such as 1,1,3,3-tetramethylisoindolin-2-oxyl, 1, and 1,1,3,3-tetraethylisoindolin-2-oxyl, 2. The limiting step in their preparation is the Grignard reaction between N-benzylphthalimide and the appropriate alkyl magnesium bromide, which typically proceeds in yields of similar to 28-40 . A microwave-assisted variation of this reaction has been optimized to give improved yields and reduced reaction times ( 45-60 and 2 h, respectively).
|Pages (from-to)||168 - 171|
|Number of pages||4|
|Journal||Australian Journal of Chemistry|
|Publication status||Published - 2008|