Synthesis of α-aminosuccinimide-containing peptides in Fmoc-based SPPS

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Abstract

Experimental conditions which influence the formation of α-aminosuccinimide (Asu) structures in Fmoc-based SPPS have been examined as part of our work on the synthesis of the hypoglycaemic peptide, Asu11-hGH[6-13] amide, and its analogues. Based on these investigations, experimental conditions for the acid- and base-catalysed cyclization of the corresponding protected aspartyl-containing peptides have been optimized to provide improved yields and reduced side product formation of these α-aminosuccinimide-containing peptides.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalLetters in Peptide Science
Volume1
Issue number6
DOIs
Publication statusPublished - 1 May 1995

Keywords

  • α-Aminosuccinimide
  • Cleavage
  • Side reaction
  • Trifluoromethane sulfonic acid

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