Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1290 - 1296 |
| Number of pages | 7 |
| Journal | MedChemComm |
| Volume | 4 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor. / Shonberg, Jeremy; Lane, Jonathan Robert David; Scammells, Peter John; Capuano, Benvenuto.
In: MedChemComm, Vol. 4, No. 9, 2013, p. 1290 - 1296.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor
AU - Shonberg, Jeremy
AU - Lane, Jonathan Robert David
AU - Scammells, Peter John
AU - Capuano, Benvenuto
PY - 2013
Y1 - 2013
N2 - Bivalent ligands represent useful tools to investigate the phenomenon of GPCR dimerization. We synthesized bivalent ligands based on (R)-apomorphine with variations in spacer length, and assessed these compounds in functional and binding assays at the dopamine D-2 receptor. The results present novel SAR for bivalent ligands targeting the D2R, and identify a relationship for spacer length with ligand potency, efficacy and affinity.
AB - Bivalent ligands represent useful tools to investigate the phenomenon of GPCR dimerization. We synthesized bivalent ligands based on (R)-apomorphine with variations in spacer length, and assessed these compounds in functional and binding assays at the dopamine D-2 receptor. The results present novel SAR for bivalent ligands targeting the D2R, and identify a relationship for spacer length with ligand potency, efficacy and affinity.
UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/Content/ArticleLanding/2013/MD/c3md00154g#!divAbstract
U2 - 10.1039/c3md00154g
DO - 10.1039/c3md00154g
M3 - Article
VL - 4
SP - 1290
EP - 1296
JO - MedChemComm
JF - MedChemComm
SN - 2040-2503
IS - 9
ER -