TY - JOUR
T1 - Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists
AU - Conway, Richard
AU - Valant, Celine
AU - Christopoulos, Arthur
AU - Robertson, Alan D
AU - Capuano, Benvenuto
AU - Crosby, Ian Travers
PY - 2012
Y1 - 2012
N2 - A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
AB - A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
UR - http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry-letters/#description
U2 - 10.1016/j.bmcl.2012.01.122
DO - 10.1016/j.bmcl.2012.01.122
M3 - Article
SN - 0960-894X
VL - 22
SP - 2560
EP - 2564
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -