Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives

Abid Hussain, Muhammad Kalim Kashif, Muhammad Moazzam Naseer, Usman A. Rana, Shahid Hameed

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10 Citations (Scopus)


A series of new 3-arylsulfonylimidazolidine-2,4-diones (2a-2p) were synthesized by reacting imidazolidine-2,4-diones (1a-1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones (1a-1e) were in turn synthesized from the corresponding ketones through Bucherer-Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR, 1H and 13C NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds (2a-2p) was evaluated using alloxanized diabetic rat model. Compound 2a showed an excellent activity with a reduction in the blood glucose level of -286 ± 7 mg/dL after 5 h of drug administration as compared to -270 ± 8 mg/dL for glipizide. The hypoglycemic activity of compound 2b (-268 ± 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound 2e.

Original languageEnglish
Pages (from-to)7313-7326
Number of pages14
JournalResearch on Chemical Intermediates
Issue number10
Publication statusPublished - 22 Oct 2015
Externally publishedYes


  • Imidazolidine-2,4-diones
  • In vivo hypoglycemic activity
  • Sulfonylureas

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