Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey, Emma E Watson, Melissa L Sykes, Amy J Jones, Jonathan Bayldon Baell, Marcel Kaiser, Vicky M Avery, Richard James Payne

Research output: Contribution to journalArticleOtherpeer-review

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.
Original languageEnglish
Pages (from-to)403 - 406
Number of pages4
JournalMedChemComm
Volume6
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., ... Payne, R. J. (2015). Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm, 6(3), 403 - 406. https://doi.org/10.1039/c4md00406j
Manos-Turvey, Alexandra ; Watson, Emma E ; Sykes, Melissa L ; Jones, Amy J ; Baell, Jonathan Bayldon ; Kaiser, Marcel ; Avery, Vicky M ; Payne, Richard James. / Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. In: MedChemComm. 2015 ; Vol. 6, No. 3. pp. 403 - 406.
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Manos-Turvey, A, Watson, EE, Sykes, ML, Jones, AJ, Baell, JB, Kaiser, M, Avery, VM & Payne, RJ 2015, 'Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents', MedChemComm, vol. 6, no. 3, pp. 403 - 406. https://doi.org/10.1039/c4md00406j

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. / Manos-Turvey, Alexandra; Watson, Emma E; Sykes, Melissa L; Jones, Amy J; Baell, Jonathan Bayldon; Kaiser, Marcel; Avery, Vicky M; Payne, Richard James.

In: MedChemComm, Vol. 6, No. 3, 2015, p. 403 - 406.

Research output: Contribution to journalArticleOtherpeer-review

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