Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey, Emma E Watson, Melissa L Sykes, Amy J Jones, Jonathan Bayldon Baell, Marcel Kaiser, Vicky M Avery, Richard James Payne

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.
Original languageEnglish
Pages (from-to)403 - 406
Number of pages4
JournalMedChemComm
Volume6
Issue number3
DOIs
Publication statusPublished - 2015

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