Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey; Emma E Watson; Melissa L Sykes; Amy J Jones; Jonathan Bayldon Baell; Marcel Kaiser; Vicky M Avery; Richard James Payne

doi:10.1039/c4md00406j

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey, Emma E Watson, Melissa L Sykes, Amy J Jones, Jonathan Bayldon Baell, Marcel Kaiser, Vicky M Avery, Richard James Payne

Medicinal Chemistry

Research output: Contribution to journal › Article › Other › peer-review

8 Citations (Scopus)

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	MedChemComm
Volume	6
Issue number	3
DOIs	https://doi.org/10.1039/c4md00406j
Publication status	Published - 2015

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10.1039/c4md00406j

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abstract = "The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.",

author = "Alexandra Manos-Turvey and Watson, {Emma E} and Sykes, {Melissa L} and Jones, {Amy J} and Baell, {Jonathan Bayldon} and Marcel Kaiser and Avery, {Vicky M} and Payne, {Richard James}",

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AU - Manos-Turvey, Alexandra

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AU - Sykes, Melissa L

AU - Jones, Amy J

AU - Baell, Jonathan Bayldon

AU - Kaiser, Marcel

AU - Avery, Vicky M

AU - Payne, Richard James

PY - 2015

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AB - The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/md/c4md00406j

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DO - 10.1039/c4md00406j

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VL - 6

SP - 403

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JO - MedChemComm

JF - MedChemComm

IS - 3

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Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Abstract

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