Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey; Emma E Watson; Melissa L Sykes; Amy J Jones; Jonathan Bayldon Baell; Marcel Kaiser; Vicky M Avery; Richard James Payne

doi:10.1039/c4md00406j

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Alexandra Manos-Turvey, Emma E Watson, Melissa L Sykes, Amy J Jones, Jonathan Bayldon Baell, Marcel Kaiser, Vicky M Avery, Richard James Payne

Medicinal Chemistry

Research output: Contribution to journal › Article › Other › peer-review

6 Citations (Scopus)

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Original language	English
Pages (from-to)	403 - 406
Number of pages	4
Journal	MedChemComm
Volume	6
Issue number	3
DOIs	https://doi.org/10.1039/c4md00406j
Publication status	Published - 2015

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10.1039/c4md00406j

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Cite this

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title = "Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents",

abstract = "The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.",

author = "Alexandra Manos-Turvey and Watson, {Emma E} and Sykes, {Melissa L} and Jones, {Amy J} and Baell, {Jonathan Bayldon} and Marcel Kaiser and Avery, {Vicky M} and Payne, {Richard James}",

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Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. / Manos-Turvey, Alexandra; Watson, Emma E; Sykes, Melissa L; Jones, Amy J; Baell, Jonathan Bayldon; Kaiser, Marcel; Avery, Vicky M; Payne, Richard James.

In: MedChemComm, Vol. 6, No. 3, 2015, p. 403 - 406.

Research output: Contribution to journal › Article › Other › peer-review

TY - JOUR

T1 - Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

AU - Manos-Turvey, Alexandra

AU - Watson, Emma E

AU - Sykes, Melissa L

AU - Jones, Amy J

AU - Baell, Jonathan Bayldon

AU - Kaiser, Marcel

AU - Avery, Vicky M

AU - Payne, Richard James

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AB - The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

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