Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent

Jia Cao; Ben Adler; Patrick Perlmutter

doi:10.1016/j.bmcl.2015.10.045

Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent

Jia Cao, Ben Adler, Patrick Perlmutter

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported

Original language	English
Pages (from-to)	5025-5027
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2015.10.045
Publication status	Published - 2015

Keywords

Isonicotinate
Total synthesis
Antibacterial
Natural product

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10.1016/j.bmcl.2015.10.045

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Cite this

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title = "Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent",

abstract = "A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported",

keywords = "Isonicotinate, Total synthesis, Antibacterial, Natural product",

author = "Jia Cao and Ben Adler and Patrick Perlmutter",

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AU - Cao, Jia

AU - Adler, Ben

AU - Perlmutter, Patrick

PY - 2015

Y1 - 2015

N2 - A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported

AB - A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported

KW - Isonicotinate

KW - Total synthesis

KW - Antibacterial

KW - Natural product

UR - http://goo.gl/NcekcD

U2 - 10.1016/j.bmcl.2015.10.045

DO - 10.1016/j.bmcl.2015.10.045

M3 - Article

VL - 25

SP - 5025

EP - 5027

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -