Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent

Jia Cao, Ben Adler, Patrick Perlmutter

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2 Citations (Scopus)


A putative antibacterial and antifungal compound, (R)-2-methylheptyl isonicotinate, was synthesized via reductive lactone alkylation of (R)-4-methyldihydrofuran-2(3H)-one. Structural characterisation data as well as bioassay results (with Bacillus subtilis or Escherichia coli) contradict those previously reported
Original languageEnglish
Pages (from-to)5025-5027
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
Publication statusPublished - 2015


  • Isonicotinate
  • Total synthesis
  • Antibacterial
  • Natural product

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