Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Balakrishna Dulla, Krishna Tulasi Kirla, Vandana Rathore, Girdhar Singh Deora, Sridhar Kavela, Subbareddy Maddika, Kiranam Chatti, Oliver Reiser, Javed Iqbal, Manojit Pal

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition. 

Original languageEnglish
Pages (from-to)3103-3107
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number19
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this