Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Balakrishna Dulla; Krishna Tulasi Kirla; Vandana Rathore; Girdhar Singh Deora; Sridhar Kavela; Subbareddy Maddika; Kiranam Chatti; Oliver Reiser; Javed Iqbal; Manojit Pal

doi:10.1039/c3ob40217g

Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Balakrishna Dulla, Krishna Tulasi Kirla, Vandana Rathore, Girdhar Singh Deora, Sridhar Kavela, Subbareddy Maddika, Kiranam Chatti, Oliver Reiser, Javed Iqbal, Manojit Pal

Research output: Contribution to journal › Article › Research › peer-review

49 Citations (Scopus)

Abstract

A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.

Original language	English
Pages (from-to)	3103-3107
Number of pages	5
Journal	Organic & Biomolecular Chemistry
Volume	11
Issue number	19
DOIs	https://doi.org/10.1039/c3ob40217g
Publication status	Published - 2013
Externally published	Yes

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10.1039/c3ob40217g

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title = "Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties",

abstract = "A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition. ",

author = "Balakrishna Dulla and Kirla, {Krishna Tulasi} and Vandana Rathore and Deora, {Girdhar Singh} and Sridhar Kavela and Subbareddy Maddika and Kiranam Chatti and Oliver Reiser and Javed Iqbal and Manojit Pal",

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doi = "10.1039/c3ob40217g",

language = "English",

volume = "11",

pages = "3103--3107",

journal = "Organic & Biomolecular Chemistry",

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publisher = "The Royal Society of Chemistry",

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Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties. / Dulla, Balakrishna; Kirla, Krishna Tulasi; Rathore, Vandana et al.
In: Organic & Biomolecular Chemistry, Vol. 11, No. 19, 2013, p. 3103-3107.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

AU - Dulla, Balakrishna

AU - Kirla, Krishna Tulasi

AU - Rathore, Vandana

AU - Deora, Girdhar Singh

AU - Kavela, Sridhar

AU - Maddika, Subbareddy

AU - Chatti, Kiranam

AU - Reiser, Oliver

AU - Iqbal, Javed

AU - Pal, Manojit

PY - 2013

Y1 - 2013

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AB - A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.

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U2 - 10.1039/c3ob40217g

DO - 10.1039/c3ob40217g

M3 - Article

C2 - 23575971

AN - SCOPUS:84876931561

SN - 1477-0520

VL - 11

SP - 3103

EP - 3107

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 19

ER -

Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Abstract

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