Synthesis and evaluation of β-carboline derivatives as inhibitors of human immunodeficiency virus

Keyur G. Brahmbhatt, Nafees Ahmed, Sudeep Sabde, Debashis Mitra, Inder Pal Singh, Kamlesh K. Bhutani

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Abstract

A series of β-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL 4.3 virus. 1-Formyl-β-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC 50 = 2.9 μM.

Original languageEnglish
Pages (from-to)4416-4419
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number15
DOIs
Publication statusPublished - 1 Aug 2010
Externally publishedYes

Keywords

  • β-Carboline
  • 1-Formyl-β-carboline
  • Anti-HIV
  • CEM-GFP cells

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