Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Raju Suresh Kumar; Mohamed Ashraf Ali; Hasnah Osman; Rusli Ismail; Tan Soo Choon; Yeong Keng Yoon; Ang Chee Wei; Suresh Pandian; Elumalai Manogaran

doi:10.1016/j.bmcl.2011.05.003

Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC ₅₀ 0.72 μmol/L.

Original language	English
Pages (from-to)	3997-4000
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2011.05.003
Publication status	Published - 1 Jul 2011
Externally published	Yes

Keywords

1,3-Dipolar cycloaddition
Acetyl cholinesterase
AchE inhibitor
Alzheimer Diseases
Azomethine ylide

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10.1016/j.bmcl.2011.05.003

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abstract = "Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC 50 0.72 μmol/L.",

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AU - Suresh Kumar, Raju

AU - Ashraf Ali, Mohamed

AU - Osman, Hasnah

AU - Ismail, Rusli

AU - Choon, Tan Soo

AU - Yoon, Yeong Keng

AU - Wei, Ang Chee

AU - Pandian, Suresh

AU - Manogaran, Elumalai

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KW - 1,3-Dipolar cycloaddition

KW - Acetyl cholinesterase

KW - AchE inhibitor

KW - Alzheimer Diseases

KW - Azomethine ylide

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Abstract

Keywords

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