Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran

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19 Citations (Scopus)

Abstract

Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC 50 0.72 μmol/L.

Original languageEnglish
Pages (from-to)3997-4000
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number13
DOIs
Publication statusPublished - 1 Jul 2011
Externally publishedYes

Keywords

  • 1,3-Dipolar cycloaddition
  • Acetyl cholinesterase
  • AchE inhibitor
  • Alzheimer Diseases
  • Azomethine ylide

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