TY - JOUR
T1 - Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino) benzoic acid
T2 - In vitro antibacterial screening activity
AU - Win, Yip Foo
AU - Teoh, Siang Guan
AU - Vikneswaran, M. R.
AU - Sivasothy, Yasodha
AU - Ha, Sie Tiong
AU - Ibrahim, Pazilah
PY - 2010/12
Y1 - 2010/12
N2 - Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R= methyl 1, butyl 3) and {3-[N(CH3)2]C6H4COO}2(C4H9)2Sn, 2 (monomer) as well as 3-[N(CH3)2]C6H4COO(C6H5)3Sn, 4 were successfully synthesized and obtained in solid state. The acid and complexes 1 - 4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C, 1H-13C HMQC & 119Sn NMR). Infrared spectroscopy showed that the coordination took place via oxygen atoms from the carboxylate anions. From 13C NMR spectroscopy data, the δ(COO) of complexes 1-4 are shifted to lower field compared to the parent acid indicated the coordination of carboxylate anion to the tin atom moiety. Moreover, the complexes obtained were screened for their in vitro antibacterial activity. Complex 4 was found to be most active against Bacillus subtilis and Staphylococcus aureus bacterial strains compared to complexes 1-3.
AB - Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R= methyl 1, butyl 3) and {3-[N(CH3)2]C6H4COO}2(C4H9)2Sn, 2 (monomer) as well as 3-[N(CH3)2]C6H4COO(C6H5)3Sn, 4 were successfully synthesized and obtained in solid state. The acid and complexes 1 - 4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C, 1H-13C HMQC & 119Sn NMR). Infrared spectroscopy showed that the coordination took place via oxygen atoms from the carboxylate anions. From 13C NMR spectroscopy data, the δ(COO) of complexes 1-4 are shifted to lower field compared to the parent acid indicated the coordination of carboxylate anion to the tin atom moiety. Moreover, the complexes obtained were screened for their in vitro antibacterial activity. Complex 4 was found to be most active against Bacillus subtilis and Staphylococcus aureus bacterial strains compared to complexes 1-3.
KW - In vitro antibacterial screening activity
KW - Organotin(IV) carboxylate
UR - http://www.scopus.com/inward/record.url?scp=79951563787&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79951563787
VL - 4
SP - 5923
EP - 5931
JO - Australian Journal of Basic and Applied Sciences
JF - Australian Journal of Basic and Applied Sciences
SN - 1991-8178
IS - 12
ER -