Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor

Gerard Peter Moloney, James Alexander Angus, Alan D Robertson, Martin J Stoermer, Michael S Robinson, Christine E Wright, Ken McRae, Arthur Christopoulos

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB1 agonists.
Original languageEnglish
Pages (from-to)513 - 539
Number of pages26
JournalEuropean Journal of Medicinal Chemistry
Volume43
Issue number1
Publication statusPublished - 2008

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