Synthesis and biological evaluation of new bis-indolyl (3-O-benzyl-1,2-O- isopropylidenexylopentadialdose-α-d-glucofuranose)

M. Shankar, A. Balasubramaniam, N. L. Gowrishankar, S. Mahendran

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1 Citation (Scopus)

Abstract

3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl-(3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives were synthesized by addition of substituted xylopentadialdose with various substituted indoles. The structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectroscopy techniques. All the synthesised compounds showed maximum zone of inhibition againt both Gram-positive and Gram-negative organisms. In the anti-inflammatory activity test, three compounds (1, 3 and 5) produced significant activity in a dose-dependent manner.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalPharmaceutical Chemistry Journal
Volume46
Issue number6
DOIs
Publication statusPublished - Sept 2012
Externally publishedYes

Keywords

  • 2-O-isopropylidene-xylopentadialdose
  • 3-O-benzyl-1
  • Anti-inflammatory activity
  • Antibacterial activity

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