Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

Nicholas Aberle; Jenny Catimel; Edouard Nice; Keith G Watson

Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

Nicholas Aberle, Jenny Catimel, Edouard Nice, Keith G Watson

Research output: Contribution to journal › Article › Research › peer-review

Abstract

A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.

Original language	English
Pages (from-to)	3741 - 3744
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	13
Publication status	Published - 2007
Externally published	Yes

Cite this

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title = "Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A",

abstract = "A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.",

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AU - Aberle, Nicholas

AU - Catimel, Jenny

AU - Nice, Edouard

AU - Watson, Keith G

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N2 - A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.

AB - A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17462892

M3 - Article

VL - 17

SP - 3741

EP - 3744

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 13

ER -

Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

Abstract

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