Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A

Nicholas Aberle, Jenny Catimel, Edouard Nice, Keith G Watson

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31 Citations (Scopus)

Abstract

A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.
Original languageEnglish
Pages (from-to)3741 - 3744
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number13
Publication statusPublished - 2007
Externally publishedYes

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