A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.
|Pages (from-to)||3741 - 3744|
|Number of pages||4|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|Publication status||Published - 2007|