Synthesis and biological activity of N-acyl-5-bromanthranilic acids

A. V. Dolzhenko, L. M. Korkodinova, V. P. Kotegov, M. V. Vasilyuk, V. V. Novikova

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Ten N-acyl-5-bromanthranilic acids have been obtained via acylation of 5-bromanthranilic acid with appropriate anhydrides. The antiinflammatory and antibacterial properties of the synthesized compounds have been evaluated. It is established that N-(o-anisoyl)-5-bromanthranilic acid possesses most pronounced antiinflammatory activity (49% inhibition of carrageenan induced paw edema in rat) and antimicrobial properties (MIC = 2.0 μg/ml with respect to St. aureus and E. coli).

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalPharmaceutical Chemistry Journal
Issue number8
Publication statusPublished - Aug 2006
Externally publishedYes

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