Synthesis and Applications of Protein/Peptide-Polymer Conjugates

Paul Wilson

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with unprecedented control over not only the polymer chain ends, but also the side chain functionality. Furthermore, this functionality can be exploited to afford chemical modification of peptides and proteins, with ever-improving site-specificity, yielding a range of well-defined protein/peptide-hybrid materials. Such materials benefit from the amalgamation of the properties of proteins/peptides with those of the synthetic (macro)molecules in question. Here, the latest developments in the synthesis of functional polymers and their use for preparation of well-defined protein/peptide-polymer conjugates will be discussed, with particular attention focused on modulating the stability, efficacy and/or administration of therapeutic peptides. (Figure presented.).

Original languageEnglish
Article number1600595
Number of pages15
JournalMacromolecular Chemistry and Physics
Volume218
Issue number9
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

Keywords

  • organic arsenicals
  • polymer therapeutics
  • precision polymerization
  • protein/peptide-polymer conjugation
  • reversible deactivation radical polymerization

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