Synthesis and antimycobacterial activity of highly functionalised pyrrolothiazole derivatives

Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar, Mohammad Asad

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A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1μM. Compound (4d) was found to be the most active with MIC of 0.231 μM and 4.372 μM respectively.

Original languageEnglish
Pages (from-to)968-974
Number of pages7
JournalLetters in Drug Design and Discovery
Issue number8
Publication statusPublished - Oct 2014
Externally publishedYes


  • Antimycobacterial activity
  • Azomethine ylide
  • Dispiroheterocycle
  • Intermolecular

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