Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Dorothy M David, Mark Robertson, Kittiya Somphol, Dean Baylis, Jonathan AV Coates, John J Deadman, Dharshini Jeevarajah, David I Rhodes

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An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).
Original languageEnglish
Pages (from-to)2611 - 2620
Number of pages10
JournalBioorganic & Medicinal Chemistry
Issue number7
Publication statusPublished - 2010
Externally publishedYes

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