Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

John B Bremner; Paul A Keller; Stephen G Pyne; Timothy P Boyle; Zinka Brkic; Dorothy M David; Mark Robertson; Kittiya Somphol; Dean Baylis; Jonathan AV Coates; John J Deadman; Dharshini Jeevarajah; David I Rhodes

doi:10.1016/j.bmc.2010.02.033

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

John B Bremner, Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Dorothy M David, Mark Robertson, Kittiya Somphol, Dean Baylis, Jonathan AV Coates, John J Deadman, Dharshini Jeevarajah, David I Rhodes

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).

Original language	English
Pages (from-to)	2611 - 2620
Number of pages	10
Journal	Bioorganic & Medicinal Chemistry
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/j.bmc.2010.02.033
Publication status	Published - 2010
Externally published	Yes

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10.1016/j.bmc.2010.02.033

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title = "Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1",

abstract = "An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).",

author = "Bremner, {John B} and Keller, {Paul A} and Pyne, {Stephen G} and Boyle, {Timothy P} and Zinka Brkic and David, {Dorothy M} and Mark Robertson and Kittiya Somphol and Dean Baylis and Coates, {Jonathan AV} and Deadman, {John J} and Dharshini Jeevarajah and Rhodes, {David I}",

year = "2010",

doi = "10.1016/j.bmc.2010.02.033",

language = "English",

volume = "18",

pages = "2611 -- 2620",

journal = "Bioorganic & Medicinal Chemistry",

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TY - JOUR

T1 - Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

AU - Bremner, John B

AU - Keller, Paul A

AU - Pyne, Stephen G

AU - Boyle, Timothy P

AU - Brkic, Zinka

AU - David, Dorothy M

AU - Robertson, Mark

AU - Somphol, Kittiya

AU - Baylis, Dean

AU - Coates, Jonathan AV

AU - Deadman, John J

AU - Jeevarajah, Dharshini

AU - Rhodes, David I

PY - 2010

Y1 - 2010

N2 - An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).

AB - An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20236828

U2 - 10.1016/j.bmc.2010.02.033

DO - 10.1016/j.bmc.2010.02.033

M3 - Article

VL - 18

SP - 2611

EP - 2620

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 7

ER -

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

Abstract

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