Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

V. A. Glushkov; O. G. Stryapunina; A. V. Dolzhenko; B. Ya Syropyatov; Yu V. Shklyaev

doi:10.1007/s11094-009-0284-1

Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

V. A. Glushkov, O. G. Stryapunina, A. V. Dolzhenko, B. Ya Syropyatov, Yu V. Shklyaev

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Three-component condensation of veratrole, isobutylene oxide, and aliphatic ω-chloronitriles via the Ritter reaction leads to 1-(ω-chloroalkyl) -6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH₄ yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Pharmaceutical Chemistry Journal
Volume	43
Issue number	5
DOIs	https://doi.org/10.1007/s11094-009-0284-1
Publication status	Published - 2009
Externally published	Yes

Keywords

Aggregation of erythrocytes
Isoquinolines
Multicomponent reactions
Nitriles
Oxiranes
Veratrole

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10.1007/s11094-009-0284-1

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title = "Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes",

abstract = "Three-component condensation of veratrole, isobutylene oxide, and aliphatic ω-chloronitriles via the Ritter reaction leads to 1-(ω-chloroalkyl) -6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.",

keywords = "Aggregation of erythrocytes, Isoquinolines, Multicomponent reactions, Nitriles, Oxiranes, Veratrole",

author = "Glushkov, \{V. A.\} and Stryapunina, \{O. G.\} and Dolzhenko, \{A. V.\} and Syropyatov, \{B. Ya\} and Shklyaev, \{Yu V.\}",

note = "Funding Information: The work was supported by a grant of the RAS Presidium program “Directed synthesis of compounds with given properties and fabrication of functional materials based on them.” Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2009",

doi = "10.1007/s11094-009-0284-1",

language = "English",

volume = "43",

pages = "245--248",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer",

number = "5",

}

TY - JOUR

T1 - Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

AU - Glushkov, V. A.

AU - Stryapunina, O. G.

AU - Dolzhenko, A. V.

AU - Syropyatov, B. Ya

AU - Shklyaev, Yu V.

N1 - Funding Information: The work was supported by a grant of the RAS Presidium program “Directed synthesis of compounds with given properties and fabrication of functional materials based on them.” Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009

Y1 - 2009

N2 - Three-component condensation of veratrole, isobutylene oxide, and aliphatic ω-chloronitriles via the Ritter reaction leads to 1-(ω-chloroalkyl) -6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.

AB - Three-component condensation of veratrole, isobutylene oxide, and aliphatic ω-chloronitriles via the Ritter reaction leads to 1-(ω-chloroalkyl) -6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.

KW - Aggregation of erythrocytes

KW - Isoquinolines

KW - Multicomponent reactions

KW - Nitriles

KW - Oxiranes

KW - Veratrole

UR - https://www.scopus.com/pages/publications/70349590311

U2 - 10.1007/s11094-009-0284-1

DO - 10.1007/s11094-009-0284-1

M3 - Article

AN - SCOPUS:70349590311

SN - 0091-150X

VL - 43

SP - 245

EP - 248

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 5

ER -

Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

Abstract

Keywords

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