A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.
|Number of pages||6|
|Journal||Acta Poloniae Pharmaceutica - Drug Research|
|Publication status||Published - 2011|