Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues

Mohamed A. Ali, Rusli Ismail, Tan S. Choon, Yeong K. Yoon, Ang C. Wei, Suresh Pandian, Jeyabalan G. Samy, Eric De Clercq, Christophe Pannecouque

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2 Citations (Scopus)

Abstract

A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalActa Poloniae Pharmaceutica - Drug Research
Volume68
Issue number3
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Anti-HIV
  • Isoxazoline

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