Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues

Mohamed A. Ali; Rusli Ismail; Tan S. Choon; Yeong K. Yoon; Ang C. Wei; Suresh Pandian; Jeyabalan G. Samy; Eric De Clercq; Christophe Pannecouque

Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues

Mohamed A. Ali, Rusli Ismail, Tan S. Choon, Yeong K. Yoon, Ang C. Wei, Suresh Pandian, Jeyabalan G. Samy, Eric De Clercq, Christophe Pannecouque

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC₅₀ of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.

Original language	English
Pages (from-to)	343-348
Number of pages	6
Journal	Acta Poloniae Pharmaceutica - Drug Research
Volume	68
Issue number	3
Publication status	Published - 2011
Externally published	Yes

Keywords

Anti-HIV
Isoxazoline

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Ali, Mohamed A. ; Ismail, Rusli ; Choon, Tan S. ; Yoon, Yeong K. ; Wei, Ang C. ; Pandian, Suresh ; Samy, Jeyabalan G. ; De Clercq, Eric ; Pannecouque, Christophe. / Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. In: Acta Poloniae Pharmaceutica - Drug Research. 2011 ; Vol. 68, No. 3. pp. 343-348.

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title = "Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues",

abstract = "A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.",

keywords = "Anti-HIV, Isoxazoline",

author = "Ali, {Mohamed A.} and Rusli Ismail and Choon, {Tan S.} and Yoon, {Yeong K.} and Wei, {Ang C.} and Suresh Pandian and Samy, {Jeyabalan G.} and {De Clercq}, Eric and Christophe Pannecouque",

year = "2011",

language = "English",

volume = "68",

pages = "343--348",

journal = "Acta Poloniae Pharmaceutica - Drug Research",

issn = "0001-6837",

publisher = "Polskie Towarzystwo Farmaceutyczne / Polish Pharmaceutical Society",

number = "3",

}

Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. / Ali, Mohamed A.; Ismail, Rusli; Choon, Tan S.; Yoon, Yeong K.; Wei, Ang C.; Pandian, Suresh; Samy, Jeyabalan G.; De Clercq, Eric; Pannecouque, Christophe.

In: Acta Poloniae Pharmaceutica - Drug Research, Vol. 68, No. 3, 2011, p. 343-348.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7- dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues

AU - Ali, Mohamed A.

AU - Ismail, Rusli

AU - Choon, Tan S.

AU - Yoon, Yeong K.

AU - Wei, Ang C.

AU - Pandian, Suresh

AU - Samy, Jeyabalan G.

AU - De Clercq, Eric

AU - Pannecouque, Christophe

PY - 2011

Y1 - 2011

N2 - A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.

AB - A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H- indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 μM and >125 μM, respectively.

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KW - Isoxazoline

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SN - 0001-6837

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