Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP

Qiang Zhang, Paul J Wilson, Athina Anastasaki, Ronan McHale, David Mark Haddleton

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Abstract

A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.
Original languageEnglish
Pages (from-to)491 - 495
Number of pages5
JournalACS Macro Letters
Volume3
Issue number5
DOIs
Publication statusPublished - 2014

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