Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP

Qiang Zhang; Paul J Wilson; Athina Anastasaki; Ronan McHale; David Mark Haddleton

doi:10.1021/mz5001724

Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP

Qiang Zhang, Paul J Wilson, Athina Anastasaki, Ronan McHale, David Mark Haddleton

Drug Delivery Disposition & Dynamics

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Abstract

A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.

Original language	English
Pages (from-to)	491 - 495
Number of pages	5
Journal	ACS Macro Letters
Volume	3
Issue number	5
DOIs	https://doi.org/10.1021/mz5001724
Publication status	Published - 2014

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10.1021/mz5001724

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title = "Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP",

abstract = "A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.",

author = "Qiang Zhang and Wilson, {Paul J} and Athina Anastasaki and Ronan McHale and Haddleton, {David Mark}",

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volume = "3",

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journal = "ACS Macro Letters",

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AU - Zhang, Qiang

AU - Wilson, Paul J

AU - Anastasaki, Athina

AU - McHale, Ronan

AU - Haddleton, David Mark

PY - 2014

Y1 - 2014

N2 - A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.

AB - A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.

UR - http://pubs.acs.org/doi/pdf/10.1021/mz5001724

U2 - 10.1021/mz5001724

DO - 10.1021/mz5001724

M3 - Article

SN - 2161-1653

VL - 3

SP - 491

EP - 495

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 5

ER -

Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP

Abstract

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