Synergistically enhance magnetic resonance/fluorescence imaging performance of responsive polymeric nanoparticles under mildly acidic biological milieu

Jinming Hu, Tao Liu, Guoying Zhang, Fan Jin, Shiyong Liu

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36 Citations (Scopus)


Core cross-linked (CCL) polymeric micelles covalently labeled with DOTA(Gd) and green- emitting NBD fluorophores within pH-responsive cores are fabricated, which can serve as a dual-modality MR/fluorescence imaging system and exhibit mildly acidic pH-triggered turn-on or enhancement of signal intensities for both imaging modalities. Compared to non-crosslinked diblock precursor, CCL micelles demonstrate better MR and fluorescence imaging performance due to structural stability and integrity endowed by the core cross-linking procedure. Furthermore, selective enhancement of MR/fluorescence imaging signal intensities of the dual-modality imaging system can also be actuated under specific intracellular microenvironments such as mildly acidic organelles.
Original languageEnglish
Pages (from-to)749 - 758
Number of pages10
JournalMacromolecular Rapid Communications
Issue number9
Publication statusPublished - 2013
Externally publishedYes

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