Synergistic combinations of polymyxins

Justin R. Lenhard; Roger L Nation; Brian T Tsuji

doi:10.1016/j.ijantimicag.2016.09.014

Synergistic combinations of polymyxins

Justin R. Lenhard, Roger L Nation, Brian T Tsuji

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Abstract

The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011–2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed.

Original language	English
Pages (from-to)	607-613
Number of pages	7
Journal	International Journal of Antimicrobial Agents
Volume	48
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2016.09.014
Publication status	Published - 1 Dec 2016

Keywords

Acinetobacter baumannii
Combinations
Klebsiella pneumoniae
Polymyxins
Pseudomonas aeruginosa
Synergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2016.09.014

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abstract = "The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011–2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed.",

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AU - Tsuji, Brian T

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AB - The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011–2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed.

KW - Acinetobacter baumannii

KW - Combinations

KW - Klebsiella pneumoniae

KW - Polymyxins

KW - Pseudomonas aeruginosa

KW - Synergy

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JO - International Journal of Antimicrobial Agents

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ER -

Synergistic combinations of polymyxins

Abstract

Keywords

UN SDGs

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