Synergistic combinations of polymyxins

Justin R. Lenhard, Roger L Nation, Brian T Tsuji

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)


The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011–2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalInternational Journal of Antimicrobial Agents
Issue number6
Publication statusPublished - 1 Dec 2016


  • Acinetobacter baumannii
  • Combinations
  • Klebsiella pneumoniae
  • Polymyxins
  • Pseudomonas aeruginosa
  • Synergy

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