Synchrotron X-Ray-Based Functional and Anatomical Lung Imaging Techniques

Sam Bayat, Christian Dullin, Marcus Kitchen, Goran Lovric

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Lung diseases are a major burden of public health especially in
developed countries and therefore continue to be an active interest in preclinical and clinical research. Due to the complex structure and motion of the lung, and in vivo or in situ analysis would be very beneficial. However, this is very challenging for virtually all imaging technologies in small animal models of lung disease due to the small size of the organ and its rapid breathing motion. To study lung disease in detail, the interaction of molecular events, anatomical alterations, and changes in the lung function need to be assessed in parallel. The use of synchrotron light sources has enabled the development of several lung imaging techniques such as phase-contrast CT, 4D lung imaging, virtual histology of lung tissue, k-edge subtraction imaging for measuring regional lung ventilation and perfusion, as well as speckle-based airflow measurements. The application of these techniques has allowed to gain more insight into anatomical alterations as well as functional parameters in small animal lung disease models, which will be demonstrated in this chapter.
Original languageEnglish
Title of host publicationAdvanced High-Resolution Tomography in Regenerative Medicine
Subtitle of host publicationThree-Dimensional Exploration into the Interactions between Tissues, Cells, and Biomaterials
EditorsAlessandra Guiliani, Alessia Cedola
Place of PublicationCham Switzerland
Number of pages17
ISBN (Electronic)9783030003685
ISBN (Print)9783030003678
Publication statusPublished - 2018

Publication series

NameFundamental Biomedical Technologies
PublisherSpringer Nature Switzerland
ISSN (Print)1559-7083

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