Synchrotron radiation intravital microscopy for preclinical imaging in rat and mouse hearts

Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai

Research output: Contribution to journalArticleOtherpeer-review


X-ray intravital microscopy using a microangiography technique was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging in rats and mice. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range. Small blood vessels around 50 um in diameter were visualized clearly. The X-ray intravital microscopy enables direct investigation of vascular functions.

Original languageEnglish
JournalKyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers
Issue number8
Publication statusPublished - 2013

Cite this