Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men

Tim R.H. Read, Gerald L. Murray, Jennifer A. Danielewski, Christopher K. Fairley, Michelle Doyle, Karen Worthington, Jenny Su, Elisa Mokany, L. T. Tan, David Lee, Lenka A. Vodstrcil, Eric P.F. Chow, Suzanne M. Garland, Marcus Y. Chen, Catriona S. Bradshaw

Research output: Contribution to journalArticleResearchpeer-review

Abstract

During 2016-2017, we tested asymptomatic men who have sex with men (MSM) in Melbourne, Australia, for Mycoplasma genitalium and macrolide resistance mutations in urine and anorectal swab specimens by using PCR. We compared M. genitalium detection rates for those asymptomatic men to those for MSM with proctitis and nongonococcal urethritis (NGU) over the same period. Of 1,001 asymptomatic MSM, 95 had M. genitalium; 84.2% were macrolide resistant, and 17% were co-infected with Neisseria gonorrhoeae or Chlamydia trachomatis. Rectal positivity for M. genitalium was 7.0% and urine positivity was 2.7%. M. genitalium was not more commonly detected in the rectums of MSM (n = 355, 5.6%) with symptoms of proctitis over the same period but was more commonly detected in MSM (n = 1,019, 8.1%) with NGU. M. genitalium is common and predominantly macrolide-resistant in asymptomatic MSM. M. genitalium is not associated with proctitis in this population.

Original languageEnglish
Pages (from-to)719-727
Number of pages9
JournalEmerging infectious diseases
Volume25
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • antibiotic resistance
  • antimicrobial resistance
  • Australia
  • azithromycin
  • bacteria
  • men who have sex with men
  • MSM
  • Mycoplasma genitalium
  • proctitis
  • sexually transmitted infections

Cite this

Read, Tim R.H. ; Murray, Gerald L. ; Danielewski, Jennifer A. ; Fairley, Christopher K. ; Doyle, Michelle ; Worthington, Karen ; Su, Jenny ; Mokany, Elisa ; Tan, L. T. ; Lee, David ; Vodstrcil, Lenka A. ; Chow, Eric P.F. ; Garland, Suzanne M. ; Chen, Marcus Y. ; Bradshaw, Catriona S. / Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men. In: Emerging infectious diseases. 2019 ; Vol. 25, No. 4. pp. 719-727.
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abstract = "During 2016-2017, we tested asymptomatic men who have sex with men (MSM) in Melbourne, Australia, for Mycoplasma genitalium and macrolide resistance mutations in urine and anorectal swab specimens by using PCR. We compared M. genitalium detection rates for those asymptomatic men to those for MSM with proctitis and nongonococcal urethritis (NGU) over the same period. Of 1,001 asymptomatic MSM, 95 had M. genitalium; 84.2{\%} were macrolide resistant, and 17{\%} were co-infected with Neisseria gonorrhoeae or Chlamydia trachomatis. Rectal positivity for M. genitalium was 7.0{\%} and urine positivity was 2.7{\%}. M. genitalium was not more commonly detected in the rectums of MSM (n = 355, 5.6{\%}) with symptoms of proctitis over the same period but was more commonly detected in MSM (n = 1,019, 8.1{\%}) with NGU. M. genitalium is common and predominantly macrolide-resistant in asymptomatic MSM. M. genitalium is not associated with proctitis in this population.",
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Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men. / Read, Tim R.H.; Murray, Gerald L.; Danielewski, Jennifer A.; Fairley, Christopher K.; Doyle, Michelle; Worthington, Karen; Su, Jenny; Mokany, Elisa; Tan, L. T. ; Lee, David; Vodstrcil, Lenka A.; Chow, Eric P.F.; Garland, Suzanne M.; Chen, Marcus Y.; Bradshaw, Catriona S.

In: Emerging infectious diseases, Vol. 25, No. 4, 01.04.2019, p. 719-727.

Research output: Contribution to journalArticleResearchpeer-review

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KW - proctitis

KW - sexually transmitted infections

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