Symptoms of depression and rates of neurocognitive impairment in HIV positive patients in Beijing, China

Rosamond Dwyer, Wenhui Lu, Lucette A Cysique, Bruce James Brew, Luxshimi Lal, Peter G Bain, Steven L Wesselingh, Edwina Jane Wright

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Background In China an estimated 780,000 people are living with HIV (PLWH). In high-income countries PLWH are at increased risk of depression, with subsequent adverse consequences for quality of life, and HIV-related morbidity and mortality. There are few data from low-and middle-income countries. The aims of this country-specific investigation of the Asia Pacific NeuroAIDS Consortium (APNAC) study were to establish the point prevalence, severity and HIV-related and non-HIV related correlates of depressive symptoms in PLWH, in Beijing, China. Method PLWH attending an outpatient clinic at Ditan Hospital, Beijing were recruited consecutively. Data sources were: study-specific questions about demographic characteristics, and health behaviours, the Centre for Epidemiological Studies Depression Scale (CES-D), the World Health Organisation Self-Reporting Questionnaire (SRQ-20) translated into Mandarin and administered as structured individual interviews, and a screen battery of four standard neuropsychological tests. Results In total 50/51 (98 ) eligible patients agreed to participate. Overall 28 scored CES-D=16 or SRQ20=10 and 18 in these clinical ranges on both measures; 69 were classified as being neuropsychologically impaired (scoring below 1 SD of the control value on at least two tests). Higher depressive symptom scores were associated with lower education, alcohol overuse and diminished motor ability (all p
Original languageEnglish
Pages (from-to)89 - 95
Number of pages7
JournalJournal of Affective Disorders
Volume162
DOIs
Publication statusPublished - 2014

Cite this

Dwyer, Rosamond ; Lu, Wenhui ; Cysique, Lucette A ; Brew, Bruce James ; Lal, Luxshimi ; Bain, Peter G ; Wesselingh, Steven L ; Wright, Edwina Jane. / Symptoms of depression and rates of neurocognitive impairment in HIV positive patients in Beijing, China. In: Journal of Affective Disorders. 2014 ; Vol. 162. pp. 89 - 95.
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abstract = "Background In China an estimated 780,000 people are living with HIV (PLWH). In high-income countries PLWH are at increased risk of depression, with subsequent adverse consequences for quality of life, and HIV-related morbidity and mortality. There are few data from low-and middle-income countries. The aims of this country-specific investigation of the Asia Pacific NeuroAIDS Consortium (APNAC) study were to establish the point prevalence, severity and HIV-related and non-HIV related correlates of depressive symptoms in PLWH, in Beijing, China. Method PLWH attending an outpatient clinic at Ditan Hospital, Beijing were recruited consecutively. Data sources were: study-specific questions about demographic characteristics, and health behaviours, the Centre for Epidemiological Studies Depression Scale (CES-D), the World Health Organisation Self-Reporting Questionnaire (SRQ-20) translated into Mandarin and administered as structured individual interviews, and a screen battery of four standard neuropsychological tests. Results In total 50/51 (98 ) eligible patients agreed to participate. Overall 28 scored CES-D=16 or SRQ20=10 and 18 in these clinical ranges on both measures; 69 were classified as being neuropsychologically impaired (scoring below 1 SD of the control value on at least two tests). Higher depressive symptom scores were associated with lower education, alcohol overuse and diminished motor ability (all p",
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Symptoms of depression and rates of neurocognitive impairment in HIV positive patients in Beijing, China. / Dwyer, Rosamond; Lu, Wenhui; Cysique, Lucette A; Brew, Bruce James; Lal, Luxshimi; Bain, Peter G; Wesselingh, Steven L; Wright, Edwina Jane.

In: Journal of Affective Disorders, Vol. 162, 2014, p. 89 - 95.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Symptoms of depression and rates of neurocognitive impairment in HIV positive patients in Beijing, China

AU - Dwyer, Rosamond

AU - Lu, Wenhui

AU - Cysique, Lucette A

AU - Brew, Bruce James

AU - Lal, Luxshimi

AU - Bain, Peter G

AU - Wesselingh, Steven L

AU - Wright, Edwina Jane

PY - 2014

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N2 - Background In China an estimated 780,000 people are living with HIV (PLWH). In high-income countries PLWH are at increased risk of depression, with subsequent adverse consequences for quality of life, and HIV-related morbidity and mortality. There are few data from low-and middle-income countries. The aims of this country-specific investigation of the Asia Pacific NeuroAIDS Consortium (APNAC) study were to establish the point prevalence, severity and HIV-related and non-HIV related correlates of depressive symptoms in PLWH, in Beijing, China. Method PLWH attending an outpatient clinic at Ditan Hospital, Beijing were recruited consecutively. Data sources were: study-specific questions about demographic characteristics, and health behaviours, the Centre for Epidemiological Studies Depression Scale (CES-D), the World Health Organisation Self-Reporting Questionnaire (SRQ-20) translated into Mandarin and administered as structured individual interviews, and a screen battery of four standard neuropsychological tests. Results In total 50/51 (98 ) eligible patients agreed to participate. Overall 28 scored CES-D=16 or SRQ20=10 and 18 in these clinical ranges on both measures; 69 were classified as being neuropsychologically impaired (scoring below 1 SD of the control value on at least two tests). Higher depressive symptom scores were associated with lower education, alcohol overuse and diminished motor ability (all p

AB - Background In China an estimated 780,000 people are living with HIV (PLWH). In high-income countries PLWH are at increased risk of depression, with subsequent adverse consequences for quality of life, and HIV-related morbidity and mortality. There are few data from low-and middle-income countries. The aims of this country-specific investigation of the Asia Pacific NeuroAIDS Consortium (APNAC) study were to establish the point prevalence, severity and HIV-related and non-HIV related correlates of depressive symptoms in PLWH, in Beijing, China. Method PLWH attending an outpatient clinic at Ditan Hospital, Beijing were recruited consecutively. Data sources were: study-specific questions about demographic characteristics, and health behaviours, the Centre for Epidemiological Studies Depression Scale (CES-D), the World Health Organisation Self-Reporting Questionnaire (SRQ-20) translated into Mandarin and administered as structured individual interviews, and a screen battery of four standard neuropsychological tests. Results In total 50/51 (98 ) eligible patients agreed to participate. Overall 28 scored CES-D=16 or SRQ20=10 and 18 in these clinical ranges on both measures; 69 were classified as being neuropsychologically impaired (scoring below 1 SD of the control value on at least two tests). Higher depressive symptom scores were associated with lower education, alcohol overuse and diminished motor ability (all p

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