Sympathetic nervous system regulation of metastasis

Matthew Pimentel, Ming Gene Chai, Caroline Phuong Le, Steven W Cole, Erica Kate Sloan

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Recent experimental and epidemiologic evidence suggests that systemic physiologic stress-responsive pathways may help shape the tumor microenvironment to promote metastasis. These pathways act through the peripheral sympathetic nervous system to release catecholaminergic neurotransmitters that stimulate signaling through b-adrenergic receptors on tumor cells and tumor-associated macrophages. Experimental studies found that chronic stress accelerated breast cancer metastasis through b-adrenergic signaling pathways that recruit alternatively activated macrophages to primary mammary tumors. Consistent with b-adrenergic regulation of breast cancer, recent clinical studies found that inhibiting b-adrenergic signaling with b-blockers was associated with improved breast-cancer specific outcomes. These and other studies described here suggest that b-blockade of sympathetic nervous system signaling pathways may be a novel adjuvant therapeutic strategy to slow cancer progression and prevent metastasis.
Original languageEnglish
Title of host publicationMetastatic Cancer: Clinical and Biological Perspectives
EditorsRahul Jandial
Place of PublicationAustin Texas USA
PublisherLandes Bioscience
Pages169 - 179
Number of pages11
ISBN (Print)9781587066597
Publication statusPublished - 2013

Cite this

Pimentel, M., Chai, M. G., Le, C. P., Cole, S. W., & Sloan, E. K. (2013). Sympathetic nervous system regulation of metastasis. In R. Jandial (Ed.), Metastatic Cancer: Clinical and Biological Perspectives (pp. 169 - 179). Austin Texas USA: Landes Bioscience.
Pimentel, Matthew ; Chai, Ming Gene ; Le, Caroline Phuong ; Cole, Steven W ; Sloan, Erica Kate. / Sympathetic nervous system regulation of metastasis. Metastatic Cancer: Clinical and Biological Perspectives. editor / Rahul Jandial. Austin Texas USA : Landes Bioscience, 2013. pp. 169 - 179
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Pimentel, M, Chai, MG, Le, CP, Cole, SW & Sloan, EK 2013, Sympathetic nervous system regulation of metastasis. in R Jandial (ed.), Metastatic Cancer: Clinical and Biological Perspectives. Landes Bioscience, Austin Texas USA, pp. 169 - 179.

Sympathetic nervous system regulation of metastasis. / Pimentel, Matthew; Chai, Ming Gene; Le, Caroline Phuong; Cole, Steven W; Sloan, Erica Kate.

Metastatic Cancer: Clinical and Biological Perspectives. ed. / Rahul Jandial. Austin Texas USA : Landes Bioscience, 2013. p. 169 - 179.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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N2 - Recent experimental and epidemiologic evidence suggests that systemic physiologic stress-responsive pathways may help shape the tumor microenvironment to promote metastasis. These pathways act through the peripheral sympathetic nervous system to release catecholaminergic neurotransmitters that stimulate signaling through b-adrenergic receptors on tumor cells and tumor-associated macrophages. Experimental studies found that chronic stress accelerated breast cancer metastasis through b-adrenergic signaling pathways that recruit alternatively activated macrophages to primary mammary tumors. Consistent with b-adrenergic regulation of breast cancer, recent clinical studies found that inhibiting b-adrenergic signaling with b-blockers was associated with improved breast-cancer specific outcomes. These and other studies described here suggest that b-blockade of sympathetic nervous system signaling pathways may be a novel adjuvant therapeutic strategy to slow cancer progression and prevent metastasis.

AB - Recent experimental and epidemiologic evidence suggests that systemic physiologic stress-responsive pathways may help shape the tumor microenvironment to promote metastasis. These pathways act through the peripheral sympathetic nervous system to release catecholaminergic neurotransmitters that stimulate signaling through b-adrenergic receptors on tumor cells and tumor-associated macrophages. Experimental studies found that chronic stress accelerated breast cancer metastasis through b-adrenergic signaling pathways that recruit alternatively activated macrophages to primary mammary tumors. Consistent with b-adrenergic regulation of breast cancer, recent clinical studies found that inhibiting b-adrenergic signaling with b-blockers was associated with improved breast-cancer specific outcomes. These and other studies described here suggest that b-blockade of sympathetic nervous system signaling pathways may be a novel adjuvant therapeutic strategy to slow cancer progression and prevent metastasis.

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Pimentel M, Chai MG, Le CP, Cole SW, Sloan EK. Sympathetic nervous system regulation of metastasis. In Jandial R, editor, Metastatic Cancer: Clinical and Biological Perspectives. Austin Texas USA: Landes Bioscience. 2013. p. 169 - 179