Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers

Claudine Kraan, Darren Robert Hocking, John Lockyer Bradshaw, Nellie Georgiou-Karistianis, Sylvia Ann Metcalfe, Alison D Archibald, Joanne Fielding, Julian Norman Trollor, Jonathon Cohen, Kim Marie Cornish

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total of 34 female PM-carriers and 33 age- and intelligence-matched controls completed an implicit symbolically primed serial reaction time task (SRTT) previously shown to be sensitive to cerebellar involvement. Implicit learning scores indicated a preservation of learning in both groups; however, PM-carriers demonstrated poorer learning through significantly elevated response latencies overall and at each specific block within the symbolic SRTT. Group comparisons also revealed a core deficit in response inhibition, alongside elevated inattentive symptoms in female PM-carriers. Finally, strong and significant associations were observed between poor symbolic SRTT performance and executive, visuospatial and affective deficits in the PM-carrier group. These associations remained strong even after controlling motor speed, and were not observed in age- and intelligence quotient-matched participants. The findings implicate cerebellar non-motor networks subserving the implicit sequencing of responses in cognitive-affective phenotypes previously observed in female PM-carriers. We contend that symbolic SRTT performance may offer clinical utility in future pharmaceutical interventions in female PM-carriers. Analysis of performance on the symbolic serial reaction time task showed that when compared with control participants, females with the PM allele had a comparable number of errors, yet significantly longer mean response latencies at each of the eight task blocks.
Original languageEnglish
Pages (from-to)385 - 393
Number of pages9
JournalGenes, Brain and Behavior
Volume13
Issue number4
DOIs
Publication statusPublished - 2014

Cite this

Kraan, Claudine ; Hocking, Darren Robert ; Bradshaw, John Lockyer ; Georgiou-Karistianis, Nellie ; Metcalfe, Sylvia Ann ; Archibald, Alison D ; Fielding, Joanne ; Trollor, Julian Norman ; Cohen, Jonathon ; Cornish, Kim Marie. / Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers. In: Genes, Brain and Behavior. 2014 ; Vol. 13, No. 4. pp. 385 - 393.
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title = "Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers",
abstract = "This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total of 34 female PM-carriers and 33 age- and intelligence-matched controls completed an implicit symbolically primed serial reaction time task (SRTT) previously shown to be sensitive to cerebellar involvement. Implicit learning scores indicated a preservation of learning in both groups; however, PM-carriers demonstrated poorer learning through significantly elevated response latencies overall and at each specific block within the symbolic SRTT. Group comparisons also revealed a core deficit in response inhibition, alongside elevated inattentive symptoms in female PM-carriers. Finally, strong and significant associations were observed between poor symbolic SRTT performance and executive, visuospatial and affective deficits in the PM-carrier group. These associations remained strong even after controlling motor speed, and were not observed in age- and intelligence quotient-matched participants. The findings implicate cerebellar non-motor networks subserving the implicit sequencing of responses in cognitive-affective phenotypes previously observed in female PM-carriers. We contend that symbolic SRTT performance may offer clinical utility in future pharmaceutical interventions in female PM-carriers. Analysis of performance on the symbolic serial reaction time task showed that when compared with control participants, females with the PM allele had a comparable number of errors, yet significantly longer mean response latencies at each of the eight task blocks.",
author = "Claudine Kraan and Hocking, {Darren Robert} and Bradshaw, {John Lockyer} and Nellie Georgiou-Karistianis and Metcalfe, {Sylvia Ann} and Archibald, {Alison D} and Joanne Fielding and Trollor, {Julian Norman} and Jonathon Cohen and Cornish, {Kim Marie}",
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language = "English",
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journal = "Genes, Brain and Behavior",
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Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers. / Kraan, Claudine; Hocking, Darren Robert; Bradshaw, John Lockyer; Georgiou-Karistianis, Nellie; Metcalfe, Sylvia Ann; Archibald, Alison D; Fielding, Joanne; Trollor, Julian Norman; Cohen, Jonathon; Cornish, Kim Marie.

In: Genes, Brain and Behavior, Vol. 13, No. 4, 2014, p. 385 - 393.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Symbolic sequence learning is associated with cognitive-affective profiles in female FMR1 premutation carriers

AU - Kraan, Claudine

AU - Hocking, Darren Robert

AU - Bradshaw, John Lockyer

AU - Georgiou-Karistianis, Nellie

AU - Metcalfe, Sylvia Ann

AU - Archibald, Alison D

AU - Fielding, Joanne

AU - Trollor, Julian Norman

AU - Cohen, Jonathon

AU - Cornish, Kim Marie

PY - 2014

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N2 - This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total of 34 female PM-carriers and 33 age- and intelligence-matched controls completed an implicit symbolically primed serial reaction time task (SRTT) previously shown to be sensitive to cerebellar involvement. Implicit learning scores indicated a preservation of learning in both groups; however, PM-carriers demonstrated poorer learning through significantly elevated response latencies overall and at each specific block within the symbolic SRTT. Group comparisons also revealed a core deficit in response inhibition, alongside elevated inattentive symptoms in female PM-carriers. Finally, strong and significant associations were observed between poor symbolic SRTT performance and executive, visuospatial and affective deficits in the PM-carrier group. These associations remained strong even after controlling motor speed, and were not observed in age- and intelligence quotient-matched participants. The findings implicate cerebellar non-motor networks subserving the implicit sequencing of responses in cognitive-affective phenotypes previously observed in female PM-carriers. We contend that symbolic SRTT performance may offer clinical utility in future pharmaceutical interventions in female PM-carriers. Analysis of performance on the symbolic serial reaction time task showed that when compared with control participants, females with the PM allele had a comparable number of errors, yet significantly longer mean response latencies at each of the eight task blocks.

AB - This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total of 34 female PM-carriers and 33 age- and intelligence-matched controls completed an implicit symbolically primed serial reaction time task (SRTT) previously shown to be sensitive to cerebellar involvement. Implicit learning scores indicated a preservation of learning in both groups; however, PM-carriers demonstrated poorer learning through significantly elevated response latencies overall and at each specific block within the symbolic SRTT. Group comparisons also revealed a core deficit in response inhibition, alongside elevated inattentive symptoms in female PM-carriers. Finally, strong and significant associations were observed between poor symbolic SRTT performance and executive, visuospatial and affective deficits in the PM-carrier group. These associations remained strong even after controlling motor speed, and were not observed in age- and intelligence quotient-matched participants. The findings implicate cerebellar non-motor networks subserving the implicit sequencing of responses in cognitive-affective phenotypes previously observed in female PM-carriers. We contend that symbolic SRTT performance may offer clinical utility in future pharmaceutical interventions in female PM-carriers. Analysis of performance on the symbolic serial reaction time task showed that when compared with control participants, females with the PM allele had a comparable number of errors, yet significantly longer mean response latencies at each of the eight task blocks.

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U2 - 10.1111/gbb.12122

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JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

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ER -