Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation

L. D. Perju-Dumbrava, M. McDonald, A. C. Kneebone, R. Long, D. Thyagarajan

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Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the 'on' and 'off' states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalJournal of Parkinson's Disease
Issue number4
Publication statusPublished - 2012
Externally publishedYes


  • deep brain stimulation
  • leucine-rich repeat kinase 2
  • PARK8
  • Parkinson's disease
  • subthalamic nucleus

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