Sustained complete remission of steroid-and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy

Jyotsna Janardan, Khai Ooi, Solomon Menahem

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Abstract

We report a case of steroid-and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months) despite CD19 recovery. Literature review suggests emerging evidence that rituximab may have a role to play in recurrent and/or refractory minimal-change disease.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalClinical Kidney Journal
Volume7
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • minimal-change disease
  • nephrotic syndrome
  • rituximab
  • steroid resistance

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