Suspended in culture - human pluripotent cells for scalable technologies

Research output: Contribution to journalLetterOther

Abstract

Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), collectively termed human pluripotent stem cells (hPSCs), are typically derived and maintained in adherent and semi-defined culture conditions. Recently a number of groups, including Chen et al., 2012, have demonstrated that hESCs can now be expanded efficiently and maintain pluripotency over long-term passaging as aggregates in a serum-free defined suspension culture system, permitting the preparation of scalable cGMP derived hPSC cultures for cell banking, high throughput research programs and clinical applications. In this short commentary we describe the utility and potential future uses of suspension culture systems for hPSCs.
Original languageEnglish
Pages (from-to)167 - 170
Number of pages4
JournalStem Cell Research
Volume9
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

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title = "Suspended in culture - human pluripotent cells for scalable technologies",
abstract = "Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), collectively termed human pluripotent stem cells (hPSCs), are typically derived and maintained in adherent and semi-defined culture conditions. Recently a number of groups, including Chen et al., 2012, have demonstrated that hESCs can now be expanded efficiently and maintain pluripotency over long-term passaging as aggregates in a serum-free defined suspension culture system, permitting the preparation of scalable cGMP derived hPSC cultures for cell banking, high throughput research programs and clinical applications. In this short commentary we describe the utility and potential future uses of suspension culture systems for hPSCs.",
author = "Carmel O'Brien and Laslett, {Andrew L}",
year = "2012",
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language = "English",
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pages = "167 -- 170",
journal = "Stem Cell Research",
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}

Suspended in culture - human pluripotent cells for scalable technologies. / O'Brien, Carmel; Laslett, Andrew L.

In: Stem Cell Research, Vol. 9, No. 2, 2012, p. 167 - 170.

Research output: Contribution to journalLetterOther

TY - JOUR

T1 - Suspended in culture - human pluripotent cells for scalable technologies

AU - O'Brien, Carmel

AU - Laslett, Andrew L

PY - 2012

Y1 - 2012

N2 - Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), collectively termed human pluripotent stem cells (hPSCs), are typically derived and maintained in adherent and semi-defined culture conditions. Recently a number of groups, including Chen et al., 2012, have demonstrated that hESCs can now be expanded efficiently and maintain pluripotency over long-term passaging as aggregates in a serum-free defined suspension culture system, permitting the preparation of scalable cGMP derived hPSC cultures for cell banking, high throughput research programs and clinical applications. In this short commentary we describe the utility and potential future uses of suspension culture systems for hPSCs.

AB - Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), collectively termed human pluripotent stem cells (hPSCs), are typically derived and maintained in adherent and semi-defined culture conditions. Recently a number of groups, including Chen et al., 2012, have demonstrated that hESCs can now be expanded efficiently and maintain pluripotency over long-term passaging as aggregates in a serum-free defined suspension culture system, permitting the preparation of scalable cGMP derived hPSC cultures for cell banking, high throughput research programs and clinical applications. In this short commentary we describe the utility and potential future uses of suspension culture systems for hPSCs.

UR - http://www.sciencedirect.com/science/article/pii/S187350611200061X

U2 - 10.1016/j.scr.2012.06.001

DO - 10.1016/j.scr.2012.06.001

M3 - Letter

VL - 9

SP - 167

EP - 170

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

IS - 2

ER -