Suspected acute hemolytic transfusion reaction mediated by anti-Dia

Ashwini Bennett, Ray K. Boyapati, Frank S. Hong

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Abstract

Anti-Dia can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Dia. Our case report details an immediate HTR due to anti-Dia in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a low-prevalence antigen.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalImmunohematology
Volume31
Issue number4
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Alloantibodies
  • Anti-Di
  • Low prevalence
  • Transfusion reaction

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