Mice defective in the ability to produce the tumor necrosis factor alpha p55 receptor (TNFαp55R) were orally challenged with a number of Salmonella typhimurium HWSH derivatives that differ in virulence. In comparison to TNFαp55R(+/+) mice, TNFαp55R(-/-) mice succumbed earlier to challenge with wild-type S. typhimurium HWSH and S. typhimurium HWSH purE. In contrast, TNFαp55R(-/-) mice were able to control an S. typhimurium HWSH aroA challenge, although greater numbers of Salmonella organisms were present in the tissues for a longer time period than was observed with TNFαp55R(+/+) mice. Vaccination of normal and TNFαp55R knockout animals with S. typhimurium HWSH aroA showed that TNFαp55R(-/-) mice, unlike TNFαp55R(+/+) mice, were not protected against a virulent S. typhimurium HWSH challenge. Splenocytes from TNFαp55R(-/-) mice exhibited a reduced ability to proliferate in the presence of S. typhimurium antigen compared to TNFαp55R(+/+) mice. Thus, TNFαp55R is essential for controlling Salmonella growth in tissues and for recall of immunity in murine salmonellosis.
|Number of pages||10|
|Journal||Infection and Immunity|
|Publication status||Published - 1 Jul 1998|