TY - JOUR
T1 - Surgical mesh coatings for infection control and temperature sensing
T2 - An in-vitro investigation
AU - Houshyar, Shadi
AU - Mirzadeh, Nedaossadat
AU - Pillai, Mamatha Muraleedharan
AU - Saha, Tanushree
AU - Khalid, Asma
AU - Bhattacharyya, Amitava
AU - Dekiwadia, Chaitali
AU - Zizhou, Rumbidzai
AU - Cryle, Max J.
AU - Payne, Jennifer A.E.
AU - Bhargava, Suresh
AU - Fox, Kate
AU - Tran, Phong A.
N1 - Funding Information:
The authors acknowledge the support from PSG Institutions, India and their facilities, and the scientific and technical assistance of the RMIT University Microscopy and Microanalysis Facility, a linked laboratory of Microscopy Australia. S.H. acknowledges the support of an RMIT Vice-Chancellor Fellowship. Anton Peleg, Monash University, kindly provided MRSA and VISA strains. We thank Roman A. Perez from Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, Spain, for the critical reading of the manuscript. Finally, KEF acknowledges the support of the Ramaciotti Foundation. S.H. conceived the study; S.H, K.F. R.Z. N.M. J.P. M.C. M.P. and P.A.T. performed experiments; S.H. and P.A.T. wrote and revised the main manuscript text. C.D. and A.B. provided scientific advice and data analysis. All authors reviewed the manuscript.
Funding Information:
The authors acknowledge the support from PSG Institutions, India and their facilities, and the scientific and technical assistance of the RMIT University Microscopy and Microanalysis Facility, a linked laboratory of Microscopy Australia. S.H. acknowledges the support of an RMIT Vice-Chancellor Fellowship. Anton Peleg, Monash University, kindly provided MRSA and VISA strains. We thank Roman A. Perez from Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, Spain, for the critical reading of the manuscript. Finally, KEF acknowledges the support of the Ramaciotti Foundation.
Publisher Copyright:
© 2021
PY - 2021/12
Y1 - 2021/12
N2 - Polypropylene (PP) remains the primary material for hernia meshes due to its biocompatibility, physical strength and ease of fabrication. However, PP meshes are still subject to complications such as mesh movement and bacterial infection that ultimately lead to mesh failure. This study describes a two-step functionalization of a PP mesh through dopamine-mediated chloro(triphenylphosphine)gold(I)/nanodiamond coatings. The gold compound provided an intrinsic surface with antimicrobial activity to the coatings, whilst the overall improvement in hydrophilicity and roughness allows for efficient adsorption of antibiotics with an aim for eradicating bacteria in the surrounding tissue. The presence of a gold compound on the surface of the mesh enhanced its contrast property, which may provide a surgical application to determine the ease of monitoring the PP mesh location after implantation inside the body to detect possible tears. Photostable negatively charged nitrogen-vacancy centres within the nanodiamonds provides an exciting possibility to optically assess locally elevated temperatures often associated with infection or excessive inflammation. The biocompatibility, antibiotic loading and associated antimicrobial properties of the coated mesh were investigated to show the potential of this new coating for future applications in hernia surgical procedures.
AB - Polypropylene (PP) remains the primary material for hernia meshes due to its biocompatibility, physical strength and ease of fabrication. However, PP meshes are still subject to complications such as mesh movement and bacterial infection that ultimately lead to mesh failure. This study describes a two-step functionalization of a PP mesh through dopamine-mediated chloro(triphenylphosphine)gold(I)/nanodiamond coatings. The gold compound provided an intrinsic surface with antimicrobial activity to the coatings, whilst the overall improvement in hydrophilicity and roughness allows for efficient adsorption of antibiotics with an aim for eradicating bacteria in the surrounding tissue. The presence of a gold compound on the surface of the mesh enhanced its contrast property, which may provide a surgical application to determine the ease of monitoring the PP mesh location after implantation inside the body to detect possible tears. Photostable negatively charged nitrogen-vacancy centres within the nanodiamonds provides an exciting possibility to optically assess locally elevated temperatures often associated with infection or excessive inflammation. The biocompatibility, antibiotic loading and associated antimicrobial properties of the coated mesh were investigated to show the potential of this new coating for future applications in hernia surgical procedures.
KW - Chloro(triphenylphosphine)gold(I)
KW - Hernia mesh
KW - Nanodiamond
KW - Polypropylene
KW - Temperature sensing
UR - http://www.scopus.com/inward/record.url?scp=85121207663&partnerID=8YFLogxK
U2 - 10.1016/j.onano.2021.100032
DO - 10.1016/j.onano.2021.100032
M3 - Article
AN - SCOPUS:85121207663
SN - 2352-9520
VL - 5
JO - OpenNano
JF - OpenNano
M1 - 100032
ER -