Surface plasmon resonance spectroscopy: a new lead in studying the membrane binding of amyloidogenic transthyretin

Xu Hou; David Henry Small; Marie Aguilar

doi:10.1007/978-1-60327-223-0_14

Surface plasmon resonance spectroscopy: a new lead in studying the membrane binding of amyloidogenic transthyretin

Xu Hou
, David Henry Small
, Marie Aguilar

Biochemistry & Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other

1 Citation (Scopus)

Abstract

Surface plasmon resonance (SPR) employs the optical principle of SPR to measure changes in mass on a sensor chip surface in real time. Surface chemistry has been developed which enables the immoblization of lipid bilayers and determination of protein-membrane interactions in real time. In the last decade, the plasma membrane has been demonstrated to play an important role in amyloidogenesis and cytotoxicity induced by amyloidogenic proteins. SPR provides an ideal way to study the membrane binding of amyloidogenic proteins. In this chapter, we describe the application of SPR to the study of amyloidogenic transthyretin binding to the plasma membrane and artificial lipid bilayers.

Original language	English
Title of host publication	Protein Folding, Misfolding and Disease - Methods and Protocols
Editors	Andrew F Hill, Kevin J Barnham, Stehen P Bottomley, Roberto Cappai
Place of Publication	USA
Publisher	Humana Press
Pages	215 - 228
Number of pages	14
Edition	1st
ISBN (Print)	9781603272216
DOIs	https://doi.org/10.1007/978-1-60327-223-0_14
Publication status	Published - 2011

Access to Document

10.1007/978-1-60327-223-0_14

Cite this

Hou, X., Small, D. H., & Aguilar, M. (2011). Surface plasmon resonance spectroscopy: a new lead in studying the membrane binding of amyloidogenic transthyretin. In A. F. Hill, K. J. Barnham, S. P. Bottomley, & R. Cappai (Eds.), Protein Folding, Misfolding and Disease - Methods and Protocols (1st ed., pp. 215 - 228). Humana Press. https://doi.org/10.1007/978-1-60327-223-0_14

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Surface plasmon resonance spectroscopy: a new lead in studying the membrane binding of amyloidogenic transthyretin. / Hou, Xu; Small, David Henry; Aguilar, Marie.
Protein Folding, Misfolding and Disease - Methods and Protocols. ed. / Andrew F Hill; Kevin J Barnham; Stehen P Bottomley; Roberto Cappai. 1st. ed. USA: Humana Press, 2011. p. 215 - 228.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other

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